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Chip Overview

The filter chips come in two types: RC (Regenerated Cellulose) and modified PES (Polyethersulfone), with various molecular weight cut-off sizes.

RC vs mPES

Feature	RC	mPES
Pore Structure	Symmetric	Asymmetric
Temperature Tolerance	Low to moderate	High
pH resistance	Moderate tolerance to extreme pHs	High tolerance to extreme pHs
Chemical Compatibility	High	Moderate
Charge	Uncharged	The sulfone group is negatively charged at pH 7.0
Hydrophilicity	High	Moderate
Thermal Stability	Lower compared to PES	Higher thermal resistance
Fouling	Very low	Low
Protein Binding	Very low	Low
Extractables	Very low	Low
Flux Rate	Moderate	High
Suitability	Preferred for charged proteins, nucleic acids, and LNPs	Preferred for uncharged biomolecules

Chip Overview

Both RC and mPES chips share the same specifications. Each filter chip consists of the following components:

Alignment Notch: Ensures correct chip positioning during installation, preventing it from being installed in reverse.

Chip Type Barcode: Identifies the type of chip.

Chip Membrane: The filtering element of the chip that separates the liquid into sample (retentate) and carrier reagent (permeate).

Liquid Port: Connects the liquid to the transfer tubing.

Housing: The outer structure of the chip encapsulates and protects the internal components.

Air Port: Channels that allow air to flow, actuating the diaphragm to control the movement of liquid.

Fastener: A component used to secure the integrity of the chip.

Chip Diaphragm: Functions to pump and suction liquid, as well as opening and closing the valve.

Note: Filter chips can be purchased from the FORMULATRIX online store at https://wcm.formulatrix.com/.